The effect of organic surfactant for stabilizing engineered functional pharmaceutical biodegradable polymeric nanoparticles

Abstract

Biodegradable polymeric nanoparticles (NPs) are produced via nanoprecipitation method also known as solvent displacement method that involved chemical reaction of organic phase to aqueous phase. The objectives of this study are to study the optimum condition of some parameters for the biodegradable polymeric nanoparticles (NPs) production by using design of experiment (DOE) approach. The recommended optimized condition that was suggested by DOE approached were; volume ratio of organic phase to aqueous phase at 10, agitation speed on aqueous phase at 1000 rpm and polymer concentration at 1 mg/mL. Under this operating condition, the model was predicted to achieve lower particle size in polymeric NPs which is at 398.126 nm. Then, the suggested optimum process parameters were applied for stabilization with the addition of polyvinylpyrrolidone (PVP) in the aqueous phase. Observation based on their color change was done for one month. The surfactant ratio was fixed at 1 wt%. The effectiveness and physico-chemical properties of functional particles in production of biodegradable polymeric NPs were investigated by using Scanning Electron Microscopic (SEM) and Fourier Transform Infrared (FTIR).