Computer-aided process design tools for debottlenecking a batch pharmaceutical production
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Date
2008-12Author
Tan, Jully
Foo, Dominic Chwan Yee, Dr.
Sivakumar, Kumaresan, Dr.
Ramlan, Abdul Aziz, Prof.
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The main objective of this work is to model and to debottleneck a batch pharmaceutical production with computer-aided process
design (CAPD) and simulation tools. An eye drop production case study is firstly modelled based on a pharmaceutical production
plant. Throughput analysis is next utilised to identify process bottlenecks that limit the increase of production and to evaluate
different debottlenecking schemes. Scheme 1 considers an effort to maximise process throughput for a single batch operation, while
Schemes 2 and 3 explore the possibility of minimising combined utilisation value of the process bottleneck. With the increase of
batch throughput, installation of a new labelling process and the addition of an intermediate tank, Scheme 3 is identified as the
debottlenecking scheme that achieves the increased production demand of 25%.
URI
http://myiem.org.my/content/iem_journal_2008-179.aspxhttp://dspace.unimap.edu.my/123456789/13626
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