| dc.contributor.author | Omar, Salem Baans | |
| dc.contributor.author | Asral Bahari, Jambek | |
| dc.date.accessioned | 2018-08-17T07:47:05Z | |
| dc.date.available | 2018-08-17T07:47:05Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Journal of Engineering Research and Education, vol.10(1), 2018, pages 27-36 (Special Issue on Bioprocess & Biosystem Engineering and their Downstream Processing) | en_US |
| dc.identifier.issn | 1823-2981 | |
| dc.identifier.uri | http://dspace.unimap.edu.my:80/xmlui/handle/123456789/55035 | |
| dc.description | Link to publisher's homepage at http://jere.unimap.edu.my | en_US |
| dc.description.abstract | Most microarray image scanning approaches provide an estimation of the intensity of the
foreground and background for each spot. Background intensity must be corrected in order
to remove the effect of the non‐specific binding or spatial heterogeneity across the array, but
when such corrections are applied many problems appear, such as negative intensity for the
spot or high variability of low‐intensity log ratios. In this paper, many alternative methods
for calculating background intensity are discussed and many approaches for background
correction are tested and compared. GenePix, ScanAlyze and QuantArry are the methods
reviewed for background intensity extraction. Four methods for background correction were
examined and the Edwards method was found to be the best and most suitable method. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Universiti Malaysia Perlis (UniMAP) | en_US |
| dc.subject | Microarray Imaging | en_US |
| dc.subject | Background Correction | en_US |
| dc.subject | DNA | en_US |
| dc.subject | Edward Method | en_US |
| dc.title | Analysis of Background Correction Methods for DNA Microarray Imaging | en_US |
| dc.type | Article | en_US |
| dc.identifier.url | http://jere.unimap.edu.my/ | |
| dc.contributor.url | omersalim4901@gmail.com | en_US |
