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dc.contributor.authorAndriani, Yosephine
dc.contributor.authorMorrow, Isabel C.
dc.contributor.authorTaran, Elena
dc.contributor.authorEdwards, Grant A.
dc.contributor.authorSchiller, Tara L.
dc.contributor.authorAzlin Fazlina, Osman
dc.contributor.authorMartin, Darren J.
dc.date.accessioned2014-03-14T07:45:54Z
dc.date.available2014-03-14T07:45:54Z
dc.date.issued2013-09
dc.identifier.citationActa Biomaterialia, vol. 9(9), 2013, pages 8308-8317en_US
dc.identifier.issn1742-7061
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1742706113002705
dc.identifier.urihttp://dspace.unimap.edu.my:80/dspace/handle/123456789/32753
dc.descriptionLink to publisher's homepage at https://www.elsevier.com/‎en_US
dc.description.abstractWe have prepared a number of silicone-based thermoplastic polyurethane (TPU) nanocomposites and demonstrated an enhancement of in vitro biostability against metal-ion-induced oxidation for potential use in long-term implantable medical devices. Organoclays based on both low-aspect-ratio hectorites and high-aspect-ratio fluoromicas were evaluated after being dual-modified with two quaternary alkyl ammonium salts with differing degrees of polarity. The resultant nanocomposites were tested for in vitro biostability using physiologically relevant oxidizing conditions. Subsequently, the effects of oxidative treatment on the surface degradation and bulk mechanical integrity of the nanocomposites were investigated and compared with the parent TPUs to identify nanocomposites with the most desirable features for long-term implantation. Here, we demonstrate that the low-aspect-ratio organohectorite was delaminated and well dispersed in the nanocomposites. Importantly, these factors gave rise to the enhanced oxidative stability. In addition, the mechanical properties of all nanocomposites were less adversely affected by the oxidative treatment compared to their parent TPUs. These results suggest the potential for improved mechanical integrity and biostability when suitable dual modified organoclays are incorporated in a silicone-based TPU.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.subjectBiomaterialen_US
dc.subjectBiostabilityen_US
dc.subjectNanocompositeen_US
dc.subjectOrganoclayen_US
dc.subjectPolyurethaneen_US
dc.titleIn vitro biostability of poly(dimethyl siloxane/hexamethylene oxide)-based polyurethane/layered silicate nanocompositesen_US
dc.typeArticleen_US
dc.contributor.urlyosephineandriani@uqconnect.edu.auen_US
dc.contributor.urlg.edwards1@uq.edu.auen_US
dc.contributor.urltara.schiller@monash.edu.auen_US
dc.contributor.urlazlin@unimap.edu.myen_US
dc.contributor.urldarren.martin@uq.edu.auen_US


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