Development of nanogap based dielectric biosensor for label-free medical diagnostic analytical measurement
Date
2009-06-20Author
A., Mat Taib
Uda, Hashim, Prof. Dr.
N. A., Yusof
Th. S., Dhahi
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Show full item recordAbstract
Biosensor with electrode distances
75 nm and highly sensitive and selective is
proposed in this research. The target application is
the label-free detection of bio-molecular
interaction for medical diagnostic analytical
measurement. The fabrication process of the
biosensor is based on conventional
photolithography, e-beam evaporation and wet
etching process. Sacrificial layer technique is
applied in this research to form nanometer gap
size between bottom and top electrode. Gold was
chosen because of its properties that inert to
atmosphere conditions and resistance to saline
solution for bio-molecules immobilization and
hybridization. For morphological and physical
characterization, SEM, TEM and AFM are will be
used while for electrical characterization, SPA and
IV-CV system is used to determine the
conductivity, capacitance and resistivity of the
device. DNA is used as a sample for testing and
the DNA extraction and preparation is done prior
to immobilization and hybridization.
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