Pharmacological molecule based on nanocarbon container encapsulated ferromagnet by combustion synthesis for cancer therapy
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Combustion synthesis in electrothermal explosion mode can be regarded as an efficient method to obtain new nanomaterials. Different starting mixtures of magnesium powder with various carbonates (Li₂CO₃, Na₂CO₃, FeCO₃, (NH₄)₂CO₃) were tried and the self-thermal reactions were carried out under both reactive (air) and neutral atmosphere (argon) with an initial pressure of 10 atm to yield novel nanomaterials,. Fe, Co, Ni, Pd, Nd, Ta, Ti ,Nb, W and NiO powders were used as catalyst and their synthesis and purification have been optimized. Under the applied conditions the presence of crystalline MgO and NaO₂ in products confirmed by XRD analysis, even for the reaction under neutral atmosphere, points to the deep conversation of carbonates. For producing fibrous products the Na₂CO₃ system proved to be the most promising one (in other of tested carbonate systems, except Li₂CO₃, the content of fibrous phase was insignificantly small). SEM images show the morphology of the products with some 1-D nanostructures resembling carbon nanotubes and nanosized metal/carbon composite (carbon-encapsulated metal-based iron nanoparticles with a core-shell structure with interesting magnetic properties by combustion was obtained. Different magnetic metals (Fe, Ni and Co) that can be encapsulated by the carbon shell, or graphite layers and nanofibers. After purification procedures, we will only obtain core-shell or graphite layers encapsulated by metal magnetic nanoparticles without impurity like nanocoated iron or carbides and amorphous carbon. The characterization techniques include the chemical analysis, HRTEM. XRD, and FESEM. The VSM and Mössbauer Spectroscopy (in the case of Fe-containing samples) will be performed in the near future. Model of the kinetic formation of pharmacological molecule based on nanostructure will be injected in the cancer tumor cell (prostate) after sterilization. The nanocontainer will be heated by microwave at the Laboratory Central of Anatomie and Cytology Pathology of the CHU Annaba. The reaction will be observed in the HRTEM.