High performance DNA sequencer for early stage HIV detection
Abstract
DNA sequence alignment aims to search for regions of homology between
biological sequences bycomparing DNAnucleotides (Adenine, Cytosine, Guanine
and Thymine) of an unknown (query) sequence against reference sequences
in a database. From biological point of views, any reference sequence with
the highest scores has the closest relationship with the query sequence, thus
characteristics of the unknown sequence could be inferred by referring to the
characteristics of the matched reference sequence. However, the execution of
DNA/protein sequencing on standard desktop computers, produces results in
hours or even days especially when dealing with longer sequences and large
database. Therefore a real time systolic array-based DNA sequencer, specifically
designed for HIV detection is developed.