A biosensor test kit for early detection of HIV-1 TAT protein

Abstract

HIV-1 is a protein (Tat protein) that sits in the virus coat of human immunodeficiency virus type 1 (HIV-1), which is the causative agent of the acquired immunodeficiency syndrome (AIDS). Therefore, a rapid, inexpensive and portable viral load monitoring tools such as electrolyte solution-gate field-effect transistor (SGFET) are of utmost importance. The SGFET is suitable to provide a higher signal-to-noise ratio, good signal stability, and highly sensitive for early detection of HIV-1 Tat protein. The potential of using MWCNTs/nanodiamonds (NOs) as a transducer via aptamer as ligand binding molecule has opened new avenues in the development of biosensors for point of care diagnostics.