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DC Field | Value | Language |
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dc.contributor.author | Xiu, Guo-Hua | - |
dc.contributor.author | Jiang, Lei | - |
dc.contributor.author | Li, Ping | - |
dc.date.accessioned | 2008-12-01T05:11:26Z | - |
dc.date.available | 2008-12-01T05:11:26Z | - |
dc.date.issued | 2001-07 | - |
dc.identifier.citation | Biotechnology and Bioengineering, vol. 74, issue 1, 2001, pages 29-39 | en_US |
dc.identifier.issn | 0006-3592 | - |
dc.identifier.uri | http://dspace.unimap.edu.my/123456789/3386 | - |
dc.description.abstract | A mathematical model has been developed for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor in which the enzyme-catalyzed reaction (the irreversible uni-uni competitive Michaelis-Menten kinetics is chosen as an example) was coupled with intraparticle diffusion, external mass transfer, and axial dispersion. The effects of mass-transfer limitations, competitive inhibition of substrates, deactivation on the enzyme effective enantioselectivity, and the optical purity and yield of the desired product are examined quantitatively over a wide range of parameters using the orthogonal collocation method. For a first-order reaction, an analytical solution is derived from the mathematical model for slab-, cylindrical-, and spherical-enzyme supports. Based on the analytical solution for the steady-state resolution process, a new concise formulation is presented to predict quantitatively the masstransfer limitations on enzyme effective enantioselectivity and optical purity and yield of the desired product for a continuous steady-state kinetic resolution process in a fixed-bed reactor. | en_US |
dc.language.iso | en | en_US |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject | Immobilized enzymes. | en_US |
dc.subject | Mass transfer. | en_US |
dc.title | Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of racemate in a fixed-bed reactor | en_US |
dc.type | Article | en_US |
Appears in Collections: | Document Delivery |
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File | Description | Size | Format | |
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Mass-transfer for limitations for immobilized enzyme- catalyzed kinetic resolution of racemate in a fixed-bed reactor..pdf | 208.9 kB | Adobe PDF | View/Open |
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