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http://hdl.handle.net/123456789/8670
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| Title: | Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst |
| Authors: | Wu, lihua
Zhou, zhongqiang
Kong, Yong Liew |
| Keywords: | Amino amide hydrochlorides
Cinchonine
Sulfonamide
Asymmetric transfer hydrogenation (ATH)
Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) |
| Issue Date: | 20-Jun-2009 |
| Publisher: | Universiti Malaysia Pahang (UMP) |
| Series/Report no.: | Proceedings of the Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) 2009 |
| Abstract: | Chiral amide ligands were synthesized
from L-proline and cinchonine and their application
to asymmetric transfer hydrogenation of prochiral
ketones was studied. Transfer hydrogen reaction
catalyzed by proline based amino amide
hydrochlorides was carried out in aqueous
HCOONa while sulfonamide derived from
cinchonin was carried out in iso-propanol
containing NaOH using [RuCl2(p-cymene)] 2 as
catalyst. The ATH of Chiral amino amide
hydrochlorides reaction yielded excellent
conversion rates of > 99% with good
enantioselectivities (up to 76.9% ee) with water as
solvent. The reaction of the substituted
acetophenone showed that the enantioselectivity
was not significantly affected by the type of
substituent on aryl but also by alkyl. |
| Description: | MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang. |
| URI: | http://hdl.handle.net/123456789/8670 |
| Appears in Collections: | Conference Papers
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| 442-445.pdf | Access is limited to UniMAP community | 663.26 kB | Adobe PDF | View/Open |
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