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Title: Amide as ligands for asymmetric transfer hydrogenation of prochiral ketones by ruthenium catalyst
Authors: Wu, lihua
Zhou, zhongqiang
Kong, Yong Liew
Keywords: Amino amide hydrochlorides;Cinchonine;Sulfonamide;Asymmetric transfer hydrogenation (ATH);Malaysian Technical Universities Conference on Engineering and Technology (MUCEET)
Issue Date: 20-Jun-2009
Publisher: Universiti Malaysia Pahang (UMP)
Series/Report no.: Proceedings of the Malaysian Technical Universities Conference on Engineering and Technology (MUCEET) 2009
Abstract: Chiral amide ligands were synthesized from L-proline and cinchonine and their application to asymmetric transfer hydrogenation of prochiral ketones was studied. Transfer hydrogen reaction catalyzed by proline based amino amide hydrochlorides was carried out in aqueous HCOONa while sulfonamide derived from cinchonin was carried out in iso-propanol containing NaOH using [RuCl2(p-cymene)] 2 as catalyst. The ATH of Chiral amino amide hydrochlorides reaction yielded excellent conversion rates of > 99% with good enantioselectivities (up to 76.9% ee) with water as solvent. The reaction of the substituted acetophenone showed that the enantioselectivity was not significantly affected by the type of substituent on aryl but also by alkyl.
Description: MUCEET 2009 is organized by Malaysian Technical Universities Network (MTUN) comprising of Universiti Malaysia Perlis (UniMAP), Universiti Tun Hussein Onn (UTHM), Universiti Teknikal Melaka (UTeM) and Universiti Malaysia Pahang (UMP), 20th - 22nd June 2009 at M. S. Garden Hotel, Kuantan, Pahang.
URI: http://hdl.handle.net/123456789/8670
Appears in Collections:Conference Papers

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