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Title: Computational modeling of Caspase activated DNAase (CAD) regulation towards Apoptosis
Authors: Mohd Yusof, Baharuddin
Keywords: Caspase activated deoxyribonuclease (CAD);ICAD;DNA fragmentation;Apoptosis;Caspase-3
Issue Date: 11-Oct-2009
Publisher: Universiti Malaysia Perlis
Citation: p.1A7 1 - 1A7 4
Series/Report no.: Proceedings of the International Conference on Man-Machine Systems (ICoMMS 2009)
Abstract: Caspase activated deoxyribonuclease (CAD) is the protein that transmit nuclear localization signal which will induced DNA fragmentation. Both CAD and its inhibitor ICAD is the key for apoptosis. As CAD is binding on RNA, ICAD-L will bind to its budding chain improving the folding. Once CAD synthesis is done, ICAD-L will still bind with CAD forming DFF which is the CAD: ICAD complex. On the contrary, ICAD-S couldn’t bind with CAD budding chain, therefore do not form DFF. When Caspase-3 is activated downstream in Caspase-3 Cascade, ICAD-L will cleaved and release active CAD to degrade DNA.
Description: Organized by School of Mechatronic Engineering (UniMAP) & co-organized by The Institution of Engineering Malaysia (IEM), 11th - 13th October 2009 at Batu Feringhi, Penang, Malaysia.
URI: http://hdl.handle.net/123456789/7267
Appears in Collections:Conference Papers

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